In this podcast episode, leading experts share key updates in the management of myelodysplastic syndromes (MDS) from ASH 2025. Amer Zeidan, MBBS, MHS, Yale School of Medicine, New Haven, CT, highlights data from the MAXILUS trial (NCT06045689), new insights from the IMerge study (NCT02598661), and early findings with bexmarilimab in higher-risk MDS (HR-MDS). This is followed by Valeria Santini, MD, University of Florence, Florence, Italy, who discusses long-term outcomes from IMerge and a post-hoc analysis of the COMMANDS trial (NCT03682536). Jacqueline Garcia, MD, Dana-Farber Cancer Institute, Boston, MA, provides perspective on the Phase III VERONA trial (NCT04401748) of azacitidine plus venetoclax in HR-MDS, and Daniel Wiseman, MBChB, PhD, University of Manchester, Manchester, UK, presents results from the Phase II AMMO study (ISRCTN30808508) in MDS-myeloproliferative neoplasm (MPN) overlap syndromes. Finally, Prof. Santini returns to address current debates and controversial topics in the diagnosis and treatment of MDS.