News

ASCO, ASH, and NCCN are pleased to acknowledge receipt of a key clarification from the Centers for Disease Control and Prevention on prescribing opioids to manage pain from certain conditions.
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When our plasma cells start producing a single cancer-causing protein rather than an array of antibody-like proteins to protect us, it's one of two arms of the Y-shaped protein that's likely to blame.
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Researchers have developed a novel approach to cancer immunotherapy, injecting immune stimulants directly into a tumor to teach the immune system to destroy it and other tumor cells throughout the body.
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When cancer escapes the immune system, our defenses are rendered powerless and are unable to fight against the disease. Chimeric antigen receptor T cells (CAR T cells) represent a promising immunotherapy strategy, developed with the aim of tackling tumors head-on.…
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In a new study, researchers have learned how a specific genetic mutation affects the maturation of blood cells in mouse models. Leukemia patients often have a mutation in this gene, often seen before the disease sets in. The researchers are…
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Researchers reveal that chimeric antigen receptor (CAR) T cells can induce tumor regression by directly targeting and killing cancer cells, uncovering new details of how these immune cells work and how their effectiveness could be improved in the treatment of…
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Although the pool of registered bone marrow donors has increased in recent years, a new study suggests that most people of southern-European and non-European descent are unlikely to have a suitable match if they need a life-saving bone marrow transplant.
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How deformable cells are, and thus how stiff or squishy they are, plays an important role in retaining blood-forming stem cells in their marrow niches and thus preserving their long-term repopulation capabilities.
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In a surprising finding, researchers showed the protein NLRP6 aggravated the difficult symptoms of gastrointestinal graft-vs.-host disease. Knocking out this protein in mice led to significantly better survival and less severe GVHD.
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Even when chronic myelogenous leukemia is in remission, 'sleeper cell,' quiescent leukemic stem cells are maintained in microenvironments in the bone marrow. This maintenance is poorly understood. Researchers now describe how niche-specific expression of a particular chemokine by a particular…
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A new drug trial has achieved a remarkable result, clearing the bone marrow of leukemia in almost 60 percent of patients.
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Chemistry researchers have patented a method for making anti-leukemia compounds that until now have only been available via an Asian tree that produces them.
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Researchers have discovered that an epigenetic protein called EZH2 delays the development of acute myeloid leukemia (AML) but then switches sides once the disease is established to help maintain tumor growth. The study suggests that targeting EZH2 could therefore be…
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The vast majority of cancer deaths occur due to the spread of cancer from one organ to another, which can happen either through the blood or the lymphatic system. However, it can be tricky to detect this early enough. Researchers…
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Doubling the low amount of total body radiation delivered to patients undergoing bone marrow transplants with donor cells that are only 'half-matched' increased the rate of engraftment from only about 50 percent to nearly 100 percent, according to a new…
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Exosomes are key to the SOS signal that the heart muscle sends out after a heart attack. Exosomes in the bloodstream carry greatly increased amounts of heart-specific microRNAs -- as seen in both mice and humans. These exosomes preferentially go…
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Our bodies are continuously concocting specific antibodies to thwart invaders like a virus or even pollen, and scientists have new information about how the essential production gets fired up and keeps up.
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