News

Researchers have demonstrated a new, rapid method to obtain donor stem cells for bone marrow transplants using a combination of Viagra and a second drug called Plerixafor. Bone marrow transplants, used mostly in the treatment of cancer, are life-saving procedures…
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A research group has discovered a novel cancer-driving mutation in the vast non-coding regions of the human cancer genome, also known as the 'dark matter' of human cancer DNA.
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A new, multicenter study has determined how a single mutation in splicing factor 3b subunit 1 (SF3B1), the most frequently mutated splicing factor gene, drives the formation of many cancers.
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A new study shows the stage at which lymphoma is originally diagnosed impacts the types of second cancers that may form after treatment.
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Researchers have identified a pair of proteins believed to be critical for spreading, or metastasizing, breast cancer to bone.
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A research team has discovered a metabolic vulnerability in multiple types of cancer cells that bear a common genetic mutation affecting cellular machines called spliceosomes.
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Yesterday, ASH President Roy Silverstein, MD, of the Medical College of Wisconsin asked members of the United States Senate Committee on Appropriations to adopt the provision in the House-passed fiscal year (FY) 2020 Labor, Health and Human Services, Education, and…
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Over half of people prescribed the targeted blood cancer-fighting drug ibrutinib developed new or worsened high blood pressure within six months of starting the medication, according to a new study published online today in Blood.
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Investigators analyzed 40 years of cancer burden data and examined patterns of incidence and mortality for various cancers, finding examples for which incidence and mortality moved in concert and examples where discordance in incidence and mortality indicate that overdiagnosis may…
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Two very different mutations have been identified as unexpected partners in crime for causing the blood cancer acute myeloid leukemia (AML). Expert analysis from CSHL helped reveal how this deadly duo is far more common in AML than thought.
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ASH has announced the names of 19 investigators who have each been awarded $150,000 through the ASH Bridge Grant Program in 2019.
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New research found that oncogene SET/TAF1, which was found to be a proto-oncogene of acute myeloid leukemia (AML), contributes to proper chromosome partitioning as a tension sensor. Additionally, abnormal SET protein disrupts tension sensor system at the centromere, leading to…
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A cluster of interacting proteins that are active in both human cancers and Tasmanian devil facial tumours, may give clues to how cancers evade the immune system, according to a new study.
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Researchers discovered new clues that provide a better understanding of why children with Down syndrome have an increased risk of leukemia.
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In experiments with mice, researchers have shown they can harness the power of iNKT cells to attack tumor cells and treat cancer. The new method suppressed the growth of multiple types of human tumors that had been transplanted into the…
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Active mutations of a certain signaling receptor protein called KIT tyrosine kinase are found in several cancers, such as acute myeloid leukemia (AML). However, the different locations in the AML cells where KIT induces cancer-specific signaling remain unclear. Now, a…
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Researchers describe a new use of leukemia drug, nilotinib, to treat a subtype of medulloblastoma, a deadly pediatric brain cancer.
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Bone marrow-derived cells play a role in changes to the mouse uterus before and during pregnancy, enabling implantation of the embryo and reducing pregnancy loss, according to new research.
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Doctors have successfully treated an infant with a rare childhood leukemia using a targeted therapy approved for adults with inoperable liver cancer and advanced kidney cancer. The decision to use the drug, sorafenib, was made after pathologists identified a unique…
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Scientists have found a vulnerability in cancer cells that could make them more susceptible to being destroyed by the immune system, according to a new report.
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