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Gene editing of bone marrow stem cells in pigtail macaques infected with simian/human immunodeficiency virus (SHIV) significantly reduces the size of dormant 'viral reservoirs' that pose a risk of reactivation.
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Chronic lymphocytic leukemia (CLL) is a hematological malignancy. When infiltrating tissues, CLL cells come in contact with healthy cells, including immune cells. Researchers have now characterized the composition of immune cells and circulating cytokines of the CLL microenvironment in mouse…
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New research shows how and where tungsten accumulates in bones of mice exposed to the element through drinking water. The findings, by a team of chemists and biologists, could add to doubts over the once-universal assumption that tungsten poses little…
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Adolescents and young adults with acute leukemia have a survival advantage if they receive treatment at a pediatric cancer center versus an adult center, according to a new study published online today in Blood Advances.
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Today, ASH announced the names of 15 investigators who have been awarded $150,000 through the ASH Bridge Grant Program, supporting promising hematology research proposals that score well but cannot be funded by the National Institutes of Health (NIH) because of…
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ASH announced a partnership with the University of North Carolina at Chapel Hill, a National Institutes of Health Clinical Genome Resource grantee, to develop a broad and accessible compendium of genomic data aimed at improving the diagnosis of some blood…
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Around 600 children under the age of 15 are diagnosed with leukemia each year in Germany. The effects are especially dramatic if this severe illness develops at birth or shortly afterwards. Research has now discovered another molecular cause for a…
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MicroRNA-17-92 is required for the T-cell and B-cell pathogenicity that drives chronic graft-versus-host disease (cGVHD) after allogeneic bone marrow transplant (BMT), report investigators. Data from cGVHD mouse models showed that, by determining T-cell and B-cell differentiation and function, miR-17-92 is…
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Prostate cancer frequently metastasizes and spreads to bone, causing severe pain, fractures, and other complications. The mechanisms that allow cancer cells to modify bone remodeling are incompletely understood. Researchers have now identified a microRNA, miR-940, that is abundant in exosomes…
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A statement by ASH’s president on the FY2018 omnibus funding package that was signed into law today by President Trump. This bill includes $37.1 billion for the NIH, a nearly 9% increase for the agency.
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A research team has begun to unravel the role of RNA epigenetics and chromatin structure in the regulation of 5-azacytidine, a DNA hypomethylating agent in certain leukemias. The results could lead to novel strategies and biomarkers that could reduce the…
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The efficacy of target specific therapies in lymphoma is limited to subgroups of patients. Scientists have identified a mechanism that confers resistance against a common therapy for lymphoma. They propose an alternative treatment that targets lymphoma signaling at its root,…
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Researchers have used computer modeling to find an existing investigational drug compound for leukemia patients to treat triple negative breast cancer once it spreads to the brain.
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Researchers have made a breakthrough in understanding the development of acute lymphoblastic leukemia, an aggressive cancer of the blood. While scientists were already familiar with many cancer-causing genes and their separate functions, the VIB team has now illustrated how two…
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The FDA recently approved the first cellular immunotherapies to treat certain blood cancers. But so far, these T cell immunotherapies can't be used if the T cells themselves are cancerous. Such 'CAR-T' cells kill each other because they resemble one…
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The American Society of Hematology and the European Hematology Association have announced the names of 20 early-career hematologists who will participate in the joint 2018 Translational Research Training in Hematology program.
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Researchers have developed a technique that allowed them to determine at diagnosis whether children with acute lymphoblastic leukemia would relapse following treatment.
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New compounds targeting epigenetics have shown remarkable early activity in patients with lymphoma, according to new data.
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