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Progress reported on understanding why Hispanic children are more likely to develop acute lymphoblastic leukemia and to die of the disease.
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Acute myeloid leukemia (AML) is the most common form of acute leukemia. It is characterized by an increase of malignant myeloid progenitor cells at the expense of mature blood cells. Only twenty-five percent of all AML patients survive five years…
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The bone marrow disease myelofibrosis is stimulated by excessive signaling from vitamin D and immune cells known as macrophages, reveals a research team. These findings could help to develop alternative treatments that do not target problem genes.
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Myeloproliferative neoplasms (MPNs) are still difficult to treat. Researchers have discovered a new therapeutic approach that could fundamentally change this situation.
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Researchers are developing a series of drug compounds that have shown promise in treating acute myeloid leukemia, an aggressive blood cancer that is one of the most lethal cancers. About 19,520 news cases are diagnosed a year, and about 10,670…
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Targeted drugs are a cornerstone of personalized medicine, yet come with important drawbacks. They restrain disease progression -- but rarely eradicate the cancer. Patients therefore need to take the drugs essentially forever, exposing them to severe side effects and incurring…
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Graft-versus-host disease (GVHD) is a major complication of bone marrow transplant, a potentially curative treatment for patients with blood-borne cancers such as leukemia and lymphoma. Inhibiting Sirt-1 in a mouse model helped control GVHD without making tumor relapse more likely,…
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Scientists find and test a promising drug that stops cancer by interfering with the cancer cells' metabolism and other circadian-related functions.
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Roy L. Silverstein, MD, a highly regarded expert in platelet and vascular cell biology as well as clinical non-malignant hematology and thrombosis, will serve as president of ASH for a year-long term through December 2019.
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Researchers used knockout mouse models created by gene editing to reveal that the miRNA miR-146b, like miR-146a, is involved in the development of cancers, with them having similar but not identical effects. The knockout mice should help in the fight…
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Immune cells engineered to attack childhood cancers were able to eradicate different types of pediatric tumors in mice, according to a new study.
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A mechanism which drives leukaemia cell growth has been discovered by researchers, who believe their findings could help to inform new strategies when it comes to treating the cancer.
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New research has identified a backup for an important biological system -- the hematopoietic system, whose adult stem cells constantly replenish the body's blood supply.
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New research means more than 90 percent of the most common cases of childhood cancer can now be classified by subtype, an advance likely to fuel precision medicine.
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Oncologists have found that a newer targeted drug is significantly more effective than standard therapy for treating elderly patients with chronic lymphocytic leukemia (CLL). The drug is taken as a pill once a day -- much more convenient than the…
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Today, the American Society of Hematology submitted feedback on draft recommendations for reforming Maintenance of Certification (MOC) to a commission appointed by the American Board of Medical Specialties (ABMS) and other entities.
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Researchers have found a stem cell enzyme copy edits more than 20 tumor types, providing new therapeutic target for preventing cancer cell resistance to chemotherapy and radiation.
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Scientists have discovered two successful therapies that slowed the progression of pediatric leukemia in mice, according to three studies published over the last two years. When a key protein responsible for leukemia, MLL, is stabilized, it slows the progression of…
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Older adults with cancer are more likely to have had a heart attack or stroke in the months prior to their cancer diagnosis compared with similar adults who do not have cancer during the same period, according to a report…
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