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The 22nd International Workshop on Non-Hodgkin Lymphoma (iwNHL) took place in Cambridge, MA, on 26-28 September, 2025. Esteemed experts gathered to discuss the latest research findings in NHL and strategies to enhance patient outcomes. iwNHL 2025 was supported by AbbVie (Platinum Supporter), Genentech (Platinum Supporter), Genmab (Platinum Supporter), Johnson & Johnson (Platinum Supporter), AstraZeneca (Gold Supporter), BMS (Gold Supporter), Kite Pharma (Gold Supporter), BeOne Medicines (Silver Supporter), Caribou Biosciences (Silver Supporter), ADC Therapeutics (Bronze Supporter), Novartis (Bronze Supporter), Nurix (Bronze Supporter), Regeneron (Bronze Supporter) and Secura Bio (Bronze Supporter). Supporters of the workshop have no influence over the production of content.

iwNHL 2025

The 22nd International Workshop on Non-Hodgkin Lymphoma
26–28 September 2025 | Cambridge, MA

iwNHL 2025

The 22nd International Workshop on Non-Hodgkin Lymphoma
26–28 September 2025 | Cambridge, MA
The 22nd International Workshop on Non-Hodgkin Lymphoma (iwNHL) took place in Cambridge, MA, on 26-28 September, 2025. Esteemed experts gathered to discuss the latest research findings in NHL and strategies to enhance patient outcomes. iwNHL 2025 was supported by AbbVie (Platinum Supporter), Genentech (Platinum Supporter), Genmab (Platinum Supporter), Johnson & Johnson (Platinum Supporter), AstraZeneca (Gold Supporter), BMS (Gold Supporter), Kite Pharma (Gold Supporter), BeOne Medicines (Silver Supporter), Caribou Biosciences (Silver Supporter), ADC Therapeutics (Bronze Supporter), Novartis (Bronze Supporter), Nurix (Bronze Supporter), Regeneron (Bronze Supporter) and Secura Bio (Bronze Supporter). Supporters of the workshop have no influence over the production of content.

Session 1: T-cell Leukemia/Lymphoma

Laurence  de Leval
Update on consensus for the next classification of hematological malignancies
Laurence de Leval Lausanne University Hospital, Lausanne, Switzerland
François Lemonnier
Pre-clinical models for precision therapy in TCLs
François Lemonnier Paris-East Créteil University, Paris, France
Salvia  Jain
PETAL Consortium: Leveraging Multimodal Global Data and Artificial Intelligence
Salvia Jain Massachusetts General Hospital, Boston, MA, United States
Francine  Foss
Aggressive T-cell lymphoma in refractory patients
Francine Foss Yale School of Medicine, New Haven, CT, United States

 

Session 2: MCL

Elaine  Jaffe
Evolution of mantle cell lymphoma: from conception to the current reality
Elaine Jaffe National Cancer Institute, Bethesda, MD, United States
Michael  Wang
Frontline therapy for MCL – which patient needs which initial regimen?
Michael Wang The University of Texas MD Anderson Cancer Center, Houston, TX, United States
Ann  LaCasce
Consolidation after frontline therapy – is autologous stem cell transplantation for MCL a thing of the past?
Ann LaCasce Dana-Farber Cancer Institute, Boston, MA, United States
Tycel Phillips
Small molecule inhibitors for relapsed MCL – one at a time or all together?
Tycel Phillips City of Hope, Duarte, CA, United States

 

Novel therapies (Part I)

Loretta Nastoupil
McAbs and ADC Combinations: Brentuximab combinations
Loretta Nastoupil The University of Texas MD Anderson Cancer Center, Houston, TX, United States
Simon Rule
Trial recruitment demographics – what is considered representative
Simon Rule University of Plymouth, Plymouth, United Kingdom
Juan Pablo Alderuccio
Loncastuximab combinations
Juan Pablo Alderuccio University of Miami, Miami, FL, United States
Gilles  Salles
Polatuzumab combinations
Gilles Salles Memorial Sloan Kettering Cancer Center, New York, NY, United States

 

Special topic: Hodgkin’s lymphoma

Alex Herrera
Beyond 2nd line
Alex Herrera City of Hope, Duarte, CA, United States
Sarah  Rutherford
HL in older adults
Sarah Rutherford Weill Cornell University, New York, NY, United States
Ann  LaCasce
1st line therapy in AYA patients with Hodgkin lymphoma
Ann LaCasce Dana-Farber Cancer Institute, Boston, MA, United States

 

Bispecific antibodies in 1st and 2nd line treatment of FL and LBCL

Elizabeth Budde
Mosunetuzumab
Elizabeth Budde City of Hope, Duarte, CA, United States
Lorenzo Falchi
Epcoritamab combinations
Lorenzo Falchi Memorial Sloan Kettering Cancer Center, New York City, NY, United States
Martin  Hutchings
Glofitamab combinations
Martin Hutchings Copenhagen University Hospital, Copenhagen, Denmark
Tycel Phillips
Plamotamab combinations
Tycel Phillips City of Hope, Duarte, CA, United States
Sameh  Gaballa
AZD0486
Sameh Gaballa Moffitt Cancer Center, Tampa, FL, United States
Jason Westin
Future perspectives with bi-and trispecific antibodies
Jason Westin The University of Texas MD Anderson Cancer Center, Houston, TX, United States

 

Novel therapies (Part II)

Loretta Nastoupil
ibrutinib
Loretta Nastoupil The University of Texas MD Anderson Cancer Center, Houston, TX, United States
Michael  Wang
Pirtobrutinib
Michael Wang The University of Texas MD Anderson Cancer Center, Houston, TX, United States
Alexey Danilov
BTK degaraders: zelebrudomide(NX-2127) & bexobrutideg (NX-5948)
Alexey Danilov City of Hope, Duarte, CA, United States
Steve Treon
BTK & BCL-2 inhibitors: novel therapies for waldenstrom’s macroglobulinemia
Steve Treon Dana-Farber Cancer Institute, Boston, MA, United States

 

Expanding the CAR platform for NHL

Real World Data

Jeremy Abramson
Liso-cel for DLBCL
Jeremy Abramson Massachusetts General Hospital Cancer Center, Boston, MA, United States
Mazyar Shadman
Axi-cel
Mazyar Shadman Fred Hutchinson Cancer Research Center, Seattle, WA, United States
Gilles  Salles
Tisa-cel
Gilles Salles Memorial Sloan Kettering Cancer Center, New York, NY, United States
Jason Westin
Future perspectives – where do we go from here?
Jason Westin The University of Texas MD Anderson Cancer Center, Houston, TX, United States
Connor  Johnson
Rapcabtagene
Connor Johnson Massachusetts General Hospital, Boston, MA, United States
Tanya  Siddiqi
Multi-targeted and in vivo CARs
Tanya Siddiqi City of Hope, Duarte, CA, United States