In this video, Rose Ellard, MSc, Kings College Hospital NHS Foundation Trust, London, UK, gives an overview of adverse effects which can result from CAR-T, including cytokine release syndrome (CRS) and neurotoxicity. She goes on to discuss a novel immune effector cell-associated neurotoxicity syndrome (ICANS) patient assessment tool. This video was recorded at the 1st European CAR T-Cell Meeting, held in Paris, France, co-organized by the European Society for Blood & Marrow Transplantation (EBMT) and the European Hematology Association (EHA).