Subarna Chakravorty, MBBS, FRCPath, MRCPCH, PhD, King’s College Hospital NHS Foundation Trust, London, UK, speaks at the British Society for Haematology (BSH) 2019 Annual Meeting, held in Glasgow, UK. She discusses the effectiveness of hydroxyurea in children with sickle cell disease (SCD) via analysis of dose-response metrics in a large birth cohort in a tertiary SCD center.