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ESH MPN 2026 | Insights into the mechanisms of disease progression in MPNs: from discovery science to the clinic

Stephen Oh, MD, PhD, Washington University School of Medicine, St. Louis, MO, provides insight into how his research exploring mechanisms of disease progression in MPNs has progressed from discovery to the clinic. Prof. Oh details how RSK1 and the DUSP6 pathway are critical in promoting disease progression and highlights an upcoming trial evaluating PMD-026 in patients with myelofibrosis. This interview took place at the ESH 11th Translational Research Conference on Myeloproliferative Neoplasms (ESH MPN 2026) in Estoril, Portugal.

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