It’s one of my areas of research, besides cord blood transplant, is really looking at conditioning regimens, specifically for patients with high-risk diseases. You know, I would say that there has been a study done in Europe using what is called a sequential conditioning regimen, which is basically a very intensive regimen as a part of chemotherapy followed right away by the transplantation...
It’s one of my areas of research, besides cord blood transplant, is really looking at conditioning regimens, specifically for patients with high-risk diseases. You know, I would say that there has been a study done in Europe using what is called a sequential conditioning regimen, which is basically a very intensive regimen as a part of chemotherapy followed right away by the transplantation. We have followed a very similar approach here in Seattle, and I’m the principal investigator of clinical trials where we use a combination of chemotherapy, specifically FLAG-IDA, followed five to four days after by a single dose of total body radiation, and then doing the transplant. We have done this specifically in patients with high-risk disease and patients with active disease or resistant to therapy. And outcomes were presented last year at the ASH meeting showing that actually many patients can be rescued now where disease-free survival at one year was above 50%. So bottom line is that there is still a lot of work to do for specifically these types of patients, but the use of sequential conditioning might overcome some of the difficulties that we encountered in the past.
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