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ASH 2025 | Fixed-duration SC mosunetuzumab in older patients with previously untreated DLBCL: MorningSun trial

Jeff Sharman, MD, Sarah Cannon Research Institute at Willamette Valley Cancer Institute & Research Center, Eugene, OR, discusses the interim results from a cohort of the Phase II MorningSun study (NCT05207670), which evaluated the efficacy and safety of fixed-duration subcutaneous (SC) mosunetuzumab monotherapy in older or unfit patients with previously untreated diffuse large B-cell lymphoma (DLBCL). Dr Sharman highlights that the study demonstrated encouraging response rates and a manageable safety profile, with low rates of cytokine release syndrome (CRS) and no reported cases of immune effector cell-associated neurotoxicity syndrome (ICANS). This interview took place at the 67th ASH Annual Meeting and Exposition, held in Orlando, FL.

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