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ASH 2025 | FEDORA preliminary analysis: fedratinib plus ropeginterferon alfa-2b in patients with myelofibrosis

Adam Mead, MA, BM, BCh, MRCP, FRCPath, PhD, Oxford University Hospitals NHS Foundation Trust, Oxford, UK, discusses the preliminary analysis of the FEDORA study (ISRCTN88102629), a Phase II trial evaluating the combination of fedratinib and ropeginterferon alfa-2b in patients with myelofibrosis (MF). Dr Mead notes that results to date are encouraging, with the combination resulting in spleen responses, symptom improvement, and reduction in JAK2 allele burden. This interview took place at the 67th ASH Annual Meeting and Exposition, held in Orlando, FL.

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