David Sallman, MD, Moffitt Cancer Center, Tampa, FL, discusses a retrospective study that investigated the impact of hematological response to frontline treatment on overall survival (OS) in lower-risk myelodysplastic syndromes (LR-MDS). Over 600 patients were included in the analysis, which showed that response rates were higher with erythroid stimulating agents (ESA) as frontline than with any second-line therapy. Hematological improvement with front- or second-line therapy was associated with improved OS, and lack of response to frontline therapy was associated with a poorer OS. This interview took place at the 65th ASH Annual Meeting and Exposition, held in San Diego, CA.
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