Catherine Bollard, MBChB, MD, FRACP, FRCPA, Children’s National Health System, Washington, DC, comments on key topics that will be discussed at the American Society of Hematology meeting in 2021. To begin with, Prof. Bollard highlights upcoming results from the a clinical trial comparing CD19 chimeric antigen receptor (CAR) T-cell therapy versus autologous stem cell transplant (ASCT) in patients with relapsed/refractory diffuse large B-cell lymphoma (DLBCL). In addition, Prof. Bollard comments on interest around new cellular therapies for blood disorders and gene therapy for sickle cell disease. This interview took place at the 2021 Relapse After HSCT² Workshop in New York, NY.