Ian Flinn, MD, PhD, Tennessee Oncology, Nashville, TN, gives an update on a Phase II study (NCT04116437) investigating the safety and efficacy of the Bruton’s tyrosine kinase inhibitor (BTKi) zanubrutinib in patients with relapsed/refractory chronic B-cell malignancies, including lymphocytic leukemia (CLL) and small lymphocytic leukemia (SLL), who have become intolerant to prior ibrutinib and/or acalabrutinib therapy. Adverse events commonly lead to discontinuation of ibrutinib and acalabrutinib, and as they are thought to be related to off-target effects, zanubrutinib has been developed with enhanced selectivity. So far, the study has found that zanubrutinib demonstrated efficacy and tolerability in CLL/SLL patients who were intolerant to previous BTKi therapies, with most previously reported adverse events not recurring with zanubrutinib use. This interview took place during the 62nd American Society of Hematology (ASH) Annual Meeting and Exposition, 2020.