Thomas J. Kipps, MD, PhD from the University of California, San Diego, CA discusses the role of embryonic protein ROR1 in the progression of chronic lymphocytic leukemia (CLL). Expressed on leukemic cells, ROR1 is a potential marker and target for CLL treatments. Prof. Kipps describes exciting data looking into the biology and signaling pathways of ROR1, and how targeted ROR1 therapies could be combined with other targeted therapies, such as ibrutinib and idelalisib, to provide a two-hit treatment approach. This interview was recorded the International Workshop on Chronic Lymphocytic Leukemia (iwCLL) 2017 held in New York, NY.