Raajit Rampal, MD, PhD, Memorial Sloan Kettering Cancer Center, New York, NY, discusses practical guidelines for the use of genomics in the treatment and management of myelofibrosis. Specifically discussed is the growing understanding of the landscape of prognostic mutations and the implications of this on treatment approaches including transplantation, and the use of targeted agents such as ruxolitinib. This interview was recorded via an online conference call with The Video Journal of Hematological Oncology (VJHemOnc).