William Wierda, MD, PhD from MD Anderson Cancer Center, Houston, TX discusses the value of prognostic markers in chronic lymphocytic leukemia (CLL). Prof. Weirda provides an overview of his presentation on precision medicine in CLL, describing how prognostic factors can be used to manage patients and to help predict clinical outcomes. Prof. Weirda details examples of genetic mutations which can act as prognostic markers and discusses how community physicians can test for these in the clinic. This interview was recorded the International Workshop on Chronic Lymphocytic Leukemia (iwCLL) 2017 held in New York, NY.