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Scientists have shown that p300, a protein that increases gene expression by attaching acetyl molecules to DNA, may stop myelodysplastic syndrome (MDS) from developing into acute myeloid leukemia (AML).
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A large, new study of adults with acute myeloid leukemia (AML) correlates 80 cancer-related gene mutations with five subtypes of AML, which are defined by the presence of specific chromosomal abnormalities. The findings might help guide mutation testing and treatment…
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Scientists identify two signaling proteins in cancer cells that make them resistant to chemotherapy, and show that blocking the proteins along with chemotherapy eliminate human leukemia in mouse models. Researchers suggest that blocking the signaling proteins c-Fos and Dusp1 as…
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ASH's President responded to the White House’s proposed fiscal year 2018 budget, which proposes a nearly $6 billion cut to the National Institutes of Health.
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Patients who are cured of Hodgkin lymphoma are at a high risk of developing a second type of cancer, particularly if they have a family history of the disease, a major new study reports.
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A researcher has found a way that prostate cancer cells hijack the body's bone maintenance, facilitating the spread of bone cancers present in some 90 percent of prostate-cancer fatalities.
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Those diagnosed at younger age or have a family history of cancer even more vulnerable
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Results from a nearly 11-year follow-up study, that showed an estimated overall survival rate of 83.3 percent, have now been published by investigators. According to the National Cancer Institute, prior to Gleevec's 2001 FDA approval, fewer than one in three CML…
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Plus, there's no evidence of safety concerns linked to long-term use of the drug, researchers say
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Significant levels of cancer-causing benzene in e-cigarette vapors can form when the devices are operated at high power, scientists have found.
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An experimental drug, LCL161, stimulates the immune system, leading to tumor shrinkage in patients affected by multiple myeloma, report scientists.
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Treatments for childhood cancers have improved to the point that 5-year survival rates are over 80 percent. However, one group has failed to benefit from these improvements, namely children who die so soon after diagnosis that they are not able…
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Using mice transplanted with human stem cells, a research team has demonstrated for the first time that the radiation encountered in deep space travel may increase the risk of leukemia in humans.
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A pair of drugs that may be a one-two punch needed to help combat acute myeloid leukemia (AML), an aggressive blood cancer that kills nearly three-fourths of patients within five years of diagnosis, is the focus of a new multi-center…
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Scientists have discovered a potential new target for the treatment of leukemia that potentially could augment the activity of BET inhibitors, drugs currently in clinical trials. These therapies act on histones, DNA's packaging proteins, to reset gene regulatory programs that…
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In response to yesterday's signing of the Administration's revised executive order on immigration (Executive Order 13780), American Society of Hematology President Kenneth C. Anderson, MD, of the Dana-Farber Cancer Institute, issued the following statement.
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In response to today’s introduction of the Cancer Drug Parity Act (H.R. 1409) by Representatives Leonard Lance (R-NJ) and Brian Higgins (D-NY), ASH President Kenneth C. Anderson, MD, of the Dana-Farber Cancer Institute, issued the following statement
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As people get older so do the hematopoietic stem cells (HSCs) that form their blood, creating an increased risk for compromised immunity and certain blood cancers. Now researchers are reporting that the bone marrow niche where HSC's form also ages,…
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A Phase III clinical trial involving 101 centers in 21 countries revealed the monoclonal antibody blinatumomab to be more effective than standard chemotherapy for treatment of advanced acute lymphoblastic leukemia (ALL).
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Anyone who uses an employee badge to enter a building may understand how a protein called ENL opens new possibilities for treating acute myeloid leukemia (AML), a fast-growing cancer of bone marrow and blood cells and the second most common…
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