Meral Beksac, MD, Ankara University, Ankara, Turkey, outlines strategies to avoid and manage post-transplant complications in multiple myeloma. Dr Beksac explains that frailty and comorbidities, as well as the choice of induction regimen prior to autologous transplantation all play a role in the incidence of complications post-transplant. In addition, it might be beneficial to reduce the conditioning intensity in some patients to avoid complications. In high-risk patients, it may also be necessary to initiate consolidation therapy earlier to prevent disease progression. This interview took place at the 48th Annual Meeting of the European Group for Blood and Marrow Transplantation (EBMT) 2022, which was held virtually.