Kostas Stamatopoulos, MD, PhD from the Institute of Applied Biosciences, Center for Research and Technology Hellas, Thessaloniki, Greece discusses how knowledge on the microenvironment and signalling pathways in chronic lymphocytic leukemia (CLL) can be translated into clinical care at the International Workshop on Chronic Lymphocytic Leukemia (iwCLL) 2017 in New York, NY. Dr Stamatopoulos emphasises the importance of a multidisciplinary team consisting of more than just physicians when trying to convert what is already known about the microenvironment in CLL into clinical practice.