At the International Workshop on Non-Hodgkin Lymphoma (iwNHL) 2015 meeting, Anas Younes, MD, of Memorial Sloan Kettering Cancer Center, New York, NY, chairs a discussion with Steven T. Rosen, MD, of City of Hope, Duarte, CA, on recent advances in the biological understanding of non-Hodgkin lymphoma and the continued need to optimize the delivery of new therapies for individual patients.