John Gribben, MD, DSc, FRCPath, FRCP FMedSci, of Barts and The London School of Medicine and Dentistry, London, UK, chairs a discussion with Wyndham Wilson, MD, PhD, of the National Cancer Institute, Bethesda, MD, on the highlights from the second day of the International Workshop on Non-Hodgkin Lymphoma (iwNHL) 2015 meeting. They explain the challenges, including the need to overcome clinical toxicities, to chimeric antigen receptor (CAR)-T cell therapy for the treatment of patients with non-Hodgkin lymphoma.