At the International Workshop on Non-Hodgkin Lymphoma (iwNHL) 2015 meeting, Francine M. Foss, MD, of the Yale University School of Medicine, New Haven, CT, chairs a discussion with Laurence de Leval, MD, PhD, of Institut universitaire de pathologie, Lausanne, Switzerland, Francesco d’Amore, MD, PhD of Aarhus University Hospital, Aarhus, Denmark, and Owen A. O’Connor, MD, PhD, Columbia University, New York, NY. Dr O’Connor summarises the current evidence on novel therapies, with an emphasis on combination regimens, for the treatment of patients with relapsed or refractory peripheral T-cell lymphoma.