The Myeloma 2016 meeting, was held in Boston, MA, from 22–24 April. Keith Stewart MB, ChB from the Mayo Clinic, discusses the day 2 highlights with Kenneth Anderson, MD of the Dana-Farber Cancer Institute, Gareth Morgan, MD, FRCP, FRCPath of the UAMS Myeloma Institute, and Jésus San Miguel of the University of Navarra. Here the experts discuss the use of immunomodulatory drugs (IMiDs), and a new class of drugs called degronimids; targeted therapies, immunotherapies and minimum residual disease (MRD).