Federico Caligaris-Cappio, MD from Vita-Salute San Raffaele University, Milan, Italy discusses with excitement the advances in chronic lymphocytic leukemia (CLL) at the International Workshop on Chronic Lymphocytic Leukemia (iwCLL) 2017 in New York, NY. Prof. Caligaris-Cappio describes how he is looking forward to seeing how scientific developments in CLL will be translated into clinical application. He specifically mentions how progress in detecting molecular and genetic abnormalities will introduce an era of personalised medicine, offering treatment that is specifically tailored to the individual patient.