Dominique Bonnet, PhD of The Francis Crick Institute, London, UK discusses the role of the microenvironment in acute myeloid leukemia (AML). Targeting of the microenvironment could be a way to impede AML tumor growth. New tools are developed to modulate the leukemic stem cells by the bone marrow microenvironment. Recorded at the 2016 National Cancer Research Institute (NCRI) Conference in Liverpool, UK.