Shaji Kumar, MD, from the Mayo Clinic, Rochester, MN talks to us about potential treatments for patients with multiple myeloma (MM) who are refractory to both immunomodulatory drugs (IMiDs) and proteasome inhibitors. Daratumumab, which has been approved for treating MM and has been shown to be even more efficacious when combined with IMiDs, is currently a major therapy for MM but the outcomes of patients with refractory MM when treated with daratumumab is unknown, as detailed by Dr. Kumar. This interview was filmed at the European Hematology Association (EHA) 2017 Annual Congress in Madrid, Spain.