Peter Hillmen, MBChB, PhD, FRCP, FRCPath, from St James’s University Hospital Leeds, Leeds, UK, gives us an overview of the Bloodwise Trials Acceleration Programme, which has sponsored many Phase II trials in the treatment of chronic lymphocytic leukemia (CLL) with novel drugs or their combinations. He also talks about the results from a Phase II trial evaluating the effectiveness and tolerability of an ibrutinib and venetolax combination in patients with CLL, noting that an impressive initial response in the peripheral blood and manageable toxicities were observed (NCT02756897). This interview was filmed at the European Hematology Association (EHA) 2017 Annual Congress in Madrid, Spain.