Prof. John Gribben (Barts Cancer Institute, London, UK) interviews Prof Andre Goy (John Theurer Cancer Center, Hackensack, NJ) at the 2014 American Society of Hematology (ASH) Annual Meeting about current strategies for managing mantle cell lymphoma in the clinic. Topics include approaches to prolong progression-free survival; patient tolerability of aggressive approaches; treatment resistance; and novel biologic therapies.