The application of JAK inhibitors in the treatment of polycythemia vera and myelofibrosis

Haifa Kathrin Al-Ali, MD from University of Leipzig, Leipzig, Germany discusses janus kinase (JAK) inhibitors at the European Hematology Association (EHA) 2016 Annual Congress in Copenhagen, Denmark. There is only one drug approved, at present, for the treatment of polycythemia vera (PV) and myelofibrosis (MF) – ruxolitinib a JAK1/JAK2 inhibitor. Dr Ali-Ali also discusses pacritinib, a JAK1 inhibitor and momelotinib, a JAK1 and JAK2 inhibitor. Fedratinib is a JAK2 inhibitor however, development of fedratinib has been halted due to safety concerns as some patients have developed Wernicke’s encephalopathy.

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