Current and potential PI3K and BTK inhibitors for CLL

Jennifer Woyach, MD of The Ohio State University Comprehensive Cancer Center, Columbus, OH gives an overview of her talk on new compounds for chronic lymphocytic leukaemia (CLL) held at the 2016 International Workshop of the German CLL Study Group (GCLLSG) in Cologne, Germany. Dr Woyach discusses the new PI3K and BTK inhibitors and the new targeted therapies, such as antibodies. With the PI3K and BTK inhibitors, the focus has been on trying to improve efficacy and minimizing toxicity. She further discusses the PI3K inhibitors duvelisib and TGR-1202. In terms of BTK inhibitors, acalabrutinib as well as GDC-0853, SNS-062 and ARQ 531.

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