Nitin Jain, MD, from the University of Texas MD Anderson Cancer Center, Houston, TX, talks to us about the implications of the positive results from clinical trials on treating chronic lymphocytic leukemia (CLL) with lenalidomide in addition to fludarabine and rituximab (NCT00860457), presented at the American Society of Oncology (ASCO) 2017 Annual Meeting in Chicago, IL. The future of treating CLL with combination regimens including ibrutinib (NCT02301156), and the need to re-design clinical trials to consider the complications of Richter’s Transformation in CLL is also discussed here.