Meletios Dimopoulos, MD, from the Athens School of Medicine, Athens, Greece, discusses combination therapies for relapsed and refractory myeloma treatment at the 2017 World Congress on Controversies in Multiple Myeloma (COMy) in Paris, France. He describes the most commonly used combinations for patients with aggressive relapse and elderly patients. Prof. Dimopoulos highlights the importance of determining if patients are refractory to particular treatments such as bortezomib or lenalidomide, in which case different regiments could be used.