Paul Richardson, MD, from the Dana-Farber Cancer Institute, Boston, MA, discusses the use of ixazomib in the treatment of multiple myeloma at the 2017 British Society for Haematology (BSH) Annual Scientific Meeting in Brighton, UK. He describes results from the randomized placebo-controlled Phase III TOURMALINE-MM2 trial (NCT01850524) of this oral proteasome inhibitor, including efficacy, tolerability and safety. Prof. Richardson also speaks about results from subgroup analyses which revealed good efficacy in pre-treated patients with high-risk cytogenetics.