At the International Workshop on Non-Hodgkin Lymphoma (iwNHL) 2015 meeting, Francine M. Foss, MD, of the Yale University School of Medicine, New Haven, CT, chairs a discussion with Laurence de Leval, MD, PhD, of Institut universitaire de pathologie, Lausanne, Switzerland, Francesco d’Amore, MD, PhD of Aarhus University Hospital, Aarhus, Denmark, and Owen A. O’Connor, MD, PhD, Columbia University, New York, NY. Professor d’Amore highlights current frontline management approaches and clinical trial data supporting the use of new approaches for patients with peripheral T-cell lymphoma.