Gareth John Morgan, MD, FRCP, FRCPath, PhD, from the Myeloma Institute, University of Arkansas for Medical Sciences, Little Rock, AR, talks to us about the potential of using combinations of immunomodulatory imide drugs (IMiDs) in the treatment of multiple myeloma (MM). He also states that although immune checkpoint inhibitor drugs haven’t been particularly successful in treating MM, there is cause for optimism in combining them with immunomodulators. IMiD combinations should be helpful for most MM patients, who are elderly and/or unfit, as described by Prof. Morgan. This interview was filmed at the American Society of Oncology (ASCO) 2017 Annual Meeting in Chicago, IL.